Sample 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 high_error_high_variance_R1 (1, 0.007560840721522623) (2, 0.006514791004057043) (3, 0.005411917808679971) (4, 0.004317754781449915) (5, 0.0032430859400727073) (6, 0.002142286594254449) (7, 0.0010701063723478176) (8, 0.0) (9, 0.0) (10, 0.0) (15, 0.0) (20, 0.0) (25, 0.0) (30, 0.0) (35, 0.0) (40, 0.0) (45, 0.0) (50, 0.0) (55, 0.0) (60, 0.0) (65, 0.0) (70, 0.0) (75, 0.0) (80, 0.0) (85, 0.0) (90, 0.0) (95, 0.0) (100, 0.0) (105, 0.0) (110, 0.0) (115, 0.0) (120, 0.0) (125, 0.0) (130, 0.0) (135, 0.0) (140, 6.520183012909958e-05) (145, 0.0012451392751116855) (150, 0.0021675875588719746) high_error_high_variance_R2 (1, 0.007569136119757877) (2, 0.006463774304910228) (3, 0.005375832826356614) (4, 0.004277936869920694) (5, 0.003207415727661114) (6, 0.0021543149216955676) (7, 0.0010713506820831057) (8, 0.0) (9, 0.0) (10, 0.0) (15, 0.0) (20, 0.0) (25, 0.0) (30, 0.0) (35, 0.0) (40, 0.0) (45, 0.0) (50, 0.0) (55, 0.0) (60, 0.0) (65, 0.0) (70, 0.0) (75, 0.0) (80, 0.0) (85, 0.0) (90, 0.0) (95, 0.0) (100, 0.0) (105, 0.0) (110, 0.0) (115, 0.0) (120, 0.0) (125, 0.0) (130, 0.0) (135, 0.0) (140, 6.586546198791993e-05) (145, 0.001236843876876431) (150, 0.002158047850901432) high_variance_R1 (1, 0.007615590349875302) (2, 0.0065181091633511445) (3, 0.005401963330797665) (4, 0.00435052160447917) (5, 0.00326631305513142) (6, 0.0021576330809896693) (7, 0.0010779870006713092) (8, 0.0) (9, 0.0) (10, 0.0) (15, 0.0) (20, 0.0) (25, 0.0) (30, 0.0) (35, 0.0) (40, 0.0) (45, 0.0) (50, 0.0) (55, 0.0) (60, 0.0) (65, 0.0) (70, 0.0) (75, 0.0) (80, 0.0) (85, 0.0) (90, 0.0) (95, 0.0) (100, 0.0) (105, 0.0) (110, 0.0) (115, 0.0) (120, 0.0) (125, 0.0) (130, 0.0) (135, 0.0) (140, 6.271321065852327e-05) (145, 0.0012657118627351163) (150, 0.0022123827093423485) high_variance_R2 (1, 0.0076342549959046236) (2, 0.006547972596998061) (3, 0.005481599153856107) (4, 0.004394072445214256) (5, 0.0032974207985136243) (6, 0.0022045020810188567) (7, 0.0011024584254653096) (8, 0.0) (9, 0.0) (10, 0.0) (15, 0.0) (20, 0.0) (25, 0.0) (30, 0.0) (35, 0.0) (40, 0.0) (45, 0.0) (50, 0.0) (55, 0.0) (60, 0.0) (65, 0.0) (70, 0.0) (75, 0.0) (80, 0.0) (85, 0.0) (90, 0.0) (95, 0.0) (100, 0.0) (105, 0.0) (110, 0.0) (115, 0.0) (120, 0.0) (125, 0.0) (130, 0.0) (135, 0.0) (140, 6.50359221643945e-05) (145, 0.001297234376029083) (150, 0.00223395074475401) low_variance_R1 (1, 0.007539272686110962) (2, 0.00646709246420433) (3, 0.0054131621184152585) (4, 0.004318999091185203) (5, 0.0032405973206021312) (6, 0.0021236219482251265) (7, 0.001050197416583207) (8, 0.0) (9, 0.0) (10, 0.0) (15, 0.0) (20, 0.0) (25, 0.0) (30, 0.0) (35, 0.0) (40, 0.0) (45, 0.0) (50, 0.0) (55, 0.0) (60, 0.0) (65, 0.0) (70, 0.0) (75, 0.0) (80, 0.0) (85, 0.0) (90, 0.0) (95, 0.0) (100, 0.0) (105, 0.0) (110, 0.0) (115, 0.0) (120, 0.0) (125, 0.0) (130, 0.0) (135, 0.0) (140, 6.370865844675379e-05) (145, 0.0012547619370645805) (150, 0.002150581992489703) low_variance_R2 (1, 0.007554619172846181) (2, 0.0064596266057926005) (3, 0.005367122658209597) (4, 0.004290379967273576) (5, 0.0032293985329845377) (6, 0.002128599187166279) (7, 0.0010597371245537495) (8, 0.0) (9, 0.0) (10, 0.0) (15, 0.0) (20, 0.0) (25, 0.0) (30, 0.0) (35, 0.0) (40, 0.0) (45, 0.0) (50, 0.0) (55, 0.0) (60, 0.0) (65, 0.0) (70, 0.0) (75, 0.0) (80, 0.0) (85, 0.0) (90, 0.0) (95, 0.0) (100, 0.0) (105, 0.0) (110, 0.0) (115, 0.0) (120, 0.0) (125, 0.0) (130, 0.0) (135, 0.0) (140, 6.2215486764408e-05) (145, 0.001238668864488187) (150, 0.0021277696473427535) medium_variance_R1 (1, 0.007601073402963607) (2, 0.006525989791674636) (3, 0.005418554127268174) (4, 0.0042949424363029655) (5, 0.003213222506425792) (6, 0.0021236219482251265) (7, 0.0010667882130537159) (8, 0.0) (9, 0.0) (10, 4.1476991176272e-07) (15, 1.65907964705088e-07) (20, 0.0) (25, 1.65907964705088e-07) (30, 4.97723894115264e-07) (35, 7.465858411728959e-07) (40, 3.31815929410176e-07) (45, 0.0) (50, 0.0) (55, 0.0) (60, 0.0) (65, 0.0) (70, 0.0) (75, 0.0) (80, 0.0) (85, 0.0) (90, 4.1476991176272e-07) (95, 1.65907964705088e-07) (100, 8.2953982352544e-08) (105, 4.1476991176272e-07) (110, 8.2953982352544e-08) (115, 4.1476991176272e-07) (120, 1.65907964705088e-07) (125, 0.0) (130, 0.0) (135, 0.0) (140, 6.412342835851651e-05) (145, 0.0012438120113940445) (150, 0.0021754681871954664) medium_variance_R2 (1, 0.007629277756963472) (2, 0.006542580588145145) (3, 0.005434315383915157) (4, 0.004350106834567408) (5, 0.0032812447719548776) (6, 0.0021543149216955676) (7, 0.0010775722307595466) (8, 0.0) (9, 0.0) (10, 0.0) (15, 0.0) (20, 0.0) (25, 0.0) (30, 0.0) (35, 4.1476991176272e-07) (40, 1.65907964705088e-07) (45, 8.2953982352544e-08) (50, 4.1476991176272e-07) (55, 3.31815929410176e-07) (60, 3.31815929410176e-07) (65, 0.0) (70, 8.2953982352544e-08) (75, 4.1476991176272e-07) (80, 8.2953982352544e-08) (85, 4.1476991176272e-07) (90, 4.97723894115264e-07) (95, 2.48861947057632e-07) (100, 0.0) (105, 0.0) (110, 0.0) (115, 0.0) (120, 1.65907964705088e-07) (125, 4.1476991176272e-07) (130, 0.0) (135, 0.0) (140, 6.122003897617747e-05) (145, 0.0012496187901587228) (150, 0.002165513709313161) only_high_error_zero_var_no_indels_R1 (1, 0.007626789137492896) (2, 0.006564978163380332) (3, 0.005480354844120819) (4, 0.004338493277038051) (5, 0.003227739453337487) (6, 0.0021630250898425846) (7, 0.0010721802219066311) (8, 0.0) (9, 0.0) (10, 0.0) (15, 0.0) (20, 0.0) (25, 0.0) (30, 0.0) (35, 0.0) (40, 0.0) (45, 0.0) (50, 0.0) (55, 0.0) (60, 0.0) (65, 0.0) (70, 0.0) (75, 0.0) (80, 0.0) (85, 0.0) (90, 0.0) (95, 0.0) (100, 0.0) (105, 0.0) (110, 0.0) (115, 0.0) (120, 0.0) (125, 0.0) (130, 0.0) (135, 0.0) (140, 6.204957879970291e-05) (145, 0.0012347700273176174) (150, 0.002144775213725025) only_high_error_zero_var_no_indels_R2 (1, 0.007645039013610455) (2, 0.006558756614703891) (3, 0.005471229906062039) (4, 0.004413566631067104) (5, 0.003292858329484234) (6, 0.002197036222607128) (7, 0.0011016288856417842) (8, 0.0) (9, 0.0) (10, 0.0) (15, 0.0) (20, 0.0) (25, 0.0) (30, 0.0) (35, 0.0) (40, 0.0) (45, 0.0) (50, 0.0) (55, 0.0) (60, 0.0) (65, 0.0) (70, 0.0) (75, 0.0) (80, 0.0) (85, 0.0) (90, 0.0) (95, 0.0) (100, 0.0) (105, 0.0) (110, 0.0) (115, 0.0) (120, 0.0) (125, 0.0) (130, 0.0) (135, 0.0) (140, 6.312798057028597e-05) (145, 0.0012329450397058615) (150, 0.00215472969160733) only_high_variance_zero_error_no_indels_R1 (1, 0.007594022314463641) (2, 0.006506080835910025) (3, 0.00539200885291536) (4, 0.004304482144273508) (5, 0.003238523471043318) (6, 0.002155559231430856) (7, 0.0010572485050831732) (8, 0.0) (9, 0.0) (10, 0.0) (15, 0.0) (20, 0.0) (25, 0.0) (30, 0.0) (35, 0.0) (40, 0.0) (45, 0.0) (50, 0.0) (55, 0.0) (60, 0.0) (65, 0.0) (70, 0.0) (75, 0.0) (80, 0.0) (85, 0.0) (90, 0.0) (95, 0.0) (100, 0.0) (105, 0.0) (110, 0.0) (115, 0.0) (120, 0.0) (125, 0.0) (130, 0.0) (135, 0.0) (140, 6.27961646408758e-05) (145, 0.0012511949158234212) (150, 0.0021592921606367202) only_high_variance_zero_error_no_indels_R2 (1, 0.007572869048963742) (2, 0.006533040880174602) (3, 0.005408184879474106) (4, 0.004345544365538017) (5, 0.0032464040993668095) (6, 0.0021543149216955676) (7, 0.001102043655553547) (8, 0.0) (9, 0.0) (10, 0.0) (15, 0.0) (20, 0.0) (25, 0.0) (30, 0.0) (35, 0.0) (40, 0.0) (45, 0.0) (50, 0.0) (55, 0.0) (60, 0.0) (65, 0.0) (70, 0.0) (75, 0.0) (80, 0.0) (85, 0.0) (90, 0.0) (95, 0.0) (100, 0.0) (105, 0.0) (110, 0.0) (115, 0.0) (120, 0.0) (125, 0.0) (130, 0.0) (135, 0.0) (140, 6.420638234086905e-05) (145, 0.0012863674043408998) (150, 0.0022090645500482467) only_low_error_zero_var_no_indels_R1 (1, 0.007649186712728082) (2, 0.006542165818233383) (3, 0.00543016768479753) (4, 0.004359231772626187) (5, 0.0032600915064549788) (6, 0.002176297727018992) (7, 0.0010763279210242583) (8, 0.0) (9, 0.0) (10, 0.0) (15, 0.0) (20, 0.0) (25, 0.0) (30, 0.0) (35, 0.0) (40, 0.0) (45, 0.0) (50, 0.0) (55, 0.0) (60, 0.0) (65, 0.0) (70, 0.0) (75, 0.0) (80, 0.0) (85, 0.0) (90, 0.0) (95, 0.0) (100, 0.0) (105, 0.0) (110, 0.0) (115, 0.0) (120, 0.0) (125, 0.0) (130, 0.0) (135, 0.0) (140, 6.204957879970291e-05) (145, 0.0012581630503410348) (150, 0.0021339911960191944) only_low_error_zero_var_no_indels_R2 (1, 0.007548812394081504) (2, 0.006493637738557144) (3, 0.005392423622827123) (4, 0.004300749215067644) (5, 0.0032157111258963684) (6, 0.002153900151783805) (7, 0.0010763279210242583) (8, 0.0) (9, 0.0) (10, 0.0) (15, 0.0) (20, 0.0) (25, 0.0) (30, 0.0) (35, 0.0) (40, 0.0) (45, 0.0) (50, 0.0) (55, 0.0) (60, 0.0) (65, 0.0) (70, 0.0) (75, 0.0) (80, 0.0) (85, 0.0) (90, 0.0) (95, 0.0) (100, 0.0) (105, 0.0) (110, 0.0) (115, 0.0) (120, 0.0) (125, 0.0) (130, 0.0) (135, 0.0) (140, 6.2215486764408e-05) (145, 0.001249950606088133) (150, 0.002197036222607128) only_low_variance_zero_error_no_indels_R1 (1, 0.0076056358719929955) (2, 0.006524330712027585) (3, 0.005467911746767938) (4, 0.004369601020420255) (5, 0.0032464040993668095) (6, 0.0021572183110779063) (7, 0.0010837937794359873) (8, 0.0) (9, 0.0) (10, 0.0) (15, 0.0) (20, 0.0) (25, 0.0) (30, 0.0) (35, 0.0) (40, 0.0) (45, 0.0) (50, 0.0) (55, 0.0) (60, 0.0) (65, 0.0) (70, 0.0) (75, 0.0) (80, 0.0) (85, 0.0) (90, 0.0) (95, 0.0) (100, 0.0) (105, 0.0) (110, 0.0) (115, 0.0) (120, 0.0) (125, 0.0) (130, 0.0) (135, 0.0) (140, 6.14689009232351e-05) (145, 0.0012715186414997944) (150, 0.0021966214526953653) only_low_variance_zero_error_no_indels_R2 (1, 0.007509409252464045) (2, 0.006463359534998466) (3, 0.005404451950268242) (4, 0.004338908046949814) (5, 0.003272949373719623) (6, 0.0021721500279013642) (7, 0.001097481186524157) (8, 0.0) (9, 0.0) (10, 0.0) (15, 0.0) (20, 0.0) (25, 0.0) (30, 0.0) (35, 0.0) (40, 0.0) (45, 0.0) (50, 0.0) (55, 0.0) (60, 0.0) (65, 0.0) (70, 0.0) (75, 0.0) (80, 0.0) (85, 0.0) (90, 0.0) (95, 0.0) (100, 0.0) (105, 0.0) (110, 0.0) (115, 0.0) (120, 0.0) (125, 0.0) (130, 0.0) (135, 0.0) (140, 5.980982127618422e-05) (145, 0.0012341893494411495) (150, 0.002143116134077974) only_medium_error_zero_var_no_indels_R1 (1, 0.007568306579934351) (2, 0.006475802632351347) (3, 0.005433071074179869) (4, 0.004346788675273305) (5, 0.0032708755241608097) (6, 0.002192473753577738) (7, 0.0010854528590830382) (8, 0.0) (9, 0.0) (10, 0.0) (15, 0.0) (20, 0.0) (25, 0.0) (30, 0.0) (35, 0.0) (40, 0.0) (45, 0.0) (50, 0.0) (55, 0.0) (60, 0.0) (65, 0.0) (70, 0.0) (75, 0.0) (80, 0.0) (85, 0.0) (90, 0.0) (95, 0.0) (100, 0.0) (105, 0.0) (110, 0.0) (115, 0.0) (120, 0.0) (125, 0.0) (130, 0.0) (135, 0.0) (140, 6.254730269381817e-05) (145, 0.0012682834361880451) (150, 0.0021733943376366525) only_medium_error_zero_var_no_indels_R2 (1, 0.007561255491434386) (2, 0.0064666776942925676) (3, 0.005376662366180139) (4, 0.0043082150734793725) (5, 0.003249722258660911) (6, 0.0021928885234895005) (7, 0.0010908448679359537) (8, 0.0) (9, 0.0) (10, 0.0) (15, 0.0) (20, 0.0) (25, 0.0) (30, 0.0) (35, 0.0) (40, 0.0) (45, 0.0) (50, 0.0) (55, 0.0) (60, 0.0) (65, 0.0) (70, 0.0) (75, 0.0) (80, 0.0) (85, 0.0) (90, 0.0) (95, 0.0) (100, 0.0) (105, 0.0) (110, 0.0) (115, 0.0) (120, 0.0) (125, 0.0) (130, 0.0) (135, 0.0) (140, 6.910066729966915e-05) (145, 0.0013193001353348599) (150, 0.0022505415412245188) only_medium_variance_zero_error_no_indels_R1 (1, 0.007536369296728622) (2, 0.006453819827027923) (3, 0.005381639605121292) (4, 0.00428955042745005) (5, 0.003217784975455182) (6, 0.002144775213725025) (7, 0.001087526708641852) (8, 0.0) (9, 0.0) (10, 0.0) (15, 0.0) (20, 0.0) (25, 0.0) (30, 0.0) (35, 0.0) (40, 0.0) (45, 0.0) (50, 0.0) (55, 0.0) (60, 0.0) (65, 0.0) (70, 0.0) (75, 0.0) (80, 0.0) (85, 0.0) (90, 0.0) (95, 0.0) (100, 0.0) (105, 0.0) (110, 0.0) (115, 0.0) (120, 0.0) (125, 0.0) (130, 0.0) (135, 0.0) (140, 6.304502658793344e-05) (145, 0.0012268893989941258) (150, 0.00215472969160733) only_medium_variance_zero_error_no_indels_R2 (1, 0.0076773910667279465) (2, 0.00657078494214501) (3, 0.00545754249897387) (4, 0.004354669303596797) (5, 0.0032190292851904693) (6, 0.002158047850901432) (7, 0.0010759131511124955) (8, 0.0) (9, 0.0) (10, 0.0) (15, 0.0) (20, 0.0) (25, 0.0) (30, 0.0) (35, 0.0) (40, 0.0) (45, 0.0) (50, 0.0) (55, 0.0) (60, 0.0) (65, 0.0) (70, 0.0) (75, 0.0) (80, 0.0) (85, 0.0) (90, 0.0) (95, 0.0) (100, 0.0) (105, 0.0) (110, 0.0) (115, 0.0) (120, 0.0) (125, 0.0) (130, 0.0) (135, 0.0) (140, 6.437229030557414e-05) (145, 0.0012707720556586215) (150, 0.0022169451783717385) reference_clean_R1 (1, 0.0074957218453758755) (2, 0.006446353968616194) (3, 0.005378736215738952) (4, 0.004298260595597067) (5, 0.0032157111258963684) (6, 0.0021874965146365852) (7, 0.0010941630272300552) (8, 0.0) (9, 0.0) (10, 0.0) (15, 0.0) (20, 0.0) (25, 0.0) (30, 0.0) (35, 0.0) (40, 0.0) (45, 0.0) (50, 0.0) (55, 0.0) (60, 0.0) (65, 0.0) (70, 0.0) (75, 0.0) (80, 0.0) (85, 0.0) (90, 0.0) (95, 0.0) (100, 0.0) (105, 0.0) (110, 0.0) (115, 0.0) (120, 0.0) (125, 0.0) (130, 0.0) (135, 0.0) (140, 6.138594694088255e-05) (145, 0.0012200042184588645) (150, 0.002124036718136889) reference_clean_R2 (1, 0.007589874615346013) (2, 0.0064807798712925) (3, 0.005406525799827055) (4, 0.004315680931891101) (5, 0.003226495143602199) (6, 0.002178786346489568) (7, 0.0010709359121713429) (8, 0.0) (9, 0.0) (10, 0.0) (15, 0.0) (20, 0.0) (25, 0.0) (30, 0.0) (35, 0.0) (40, 0.0) (45, 0.0) (50, 0.0) (55, 0.0) (60, 0.0) (65, 0.0) (70, 0.0) (75, 0.0) (80, 0.0) (85, 0.0) (90, 0.0) (95, 0.0) (100, 0.0) (105, 0.0) (110, 0.0) (115, 0.0) (120, 0.0) (125, 0.0) (130, 0.0) (135, 0.0) (140, 6.495296818204194e-05) (145, 0.0012602368998998483) (150, 0.002160121700460246)