Sample 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 high_error_high_variance_R1 (0.0, 528.0) (1.0, 953.5) (2.0, 1824.0) (3.0, 2705.5) (4.0, 3650.5) (5.0, 4661.0) (6.0, 5979.5) (7.0, 7560.0) (8.0, 9524.0) (9.0, 12270.0) (10.0, 16115.5) (11.0, 21728.5) (12.0, 29554.0) (13.0, 40284.0) (14.0, 55837.5) (15.0, 78419.5) (16.0, 111729.0) (17.0, 160990.5) (18.0, 232248.5) (19.0, 335957.5) (20.0, 484331.0) (21.0, 688483.5) (22.0, 962158.5) (23.0, 1319370.5) (24.0, 1770671.0) (25.0, 2319610.0) (26.0, 2958265.0) (27.0, 3672585.0) (28.0, 4443473.5) (29.0, 5243914.5) (30.0, 6041581.0) (31.0, 6803522.0) (32.0, 7499145.5) (33.0, 8107289.5) (34.0, 8614570.5) (35.0, 9002300.5) (36.0, 9257935.0) (37.0, 9374611.5) (38.0, 9366784.5) (39.0, 9254298.5) (40.0, 9043783.5) (41.0, 8756465.0) (42.0, 8409403.0) (43.0, 8018354.0) (44.0, 7603493.0) (45.0, 7184415.5) (46.0, 6773411.0) (47.0, 6381981.0) (48.0, 6009122.0) (49.0, 5651164.0) (50.0, 5312285.0) (51.0, 4988385.0) (52.0, 4683382.0) (53.0, 4395494.5) (54.0, 4125226.0) (55.0, 3869456.5) (56.0, 3618601.5) (57.0, 3365867.5) (58.0, 3107333.0) (59.0, 2846149.0) (60.0, 2581326.5) (61.0, 2314126.5) (62.0, 2050997.0) (63.0, 1799029.5) (64.0, 1564815.0) (65.0, 1351209.5) (66.0, 1156055.5) (67.0, 978732.5) (68.0, 821874.0) (69.0, 684456.0) (70.0, 567802.5) (71.0, 473712.0) (72.0, 397445.5) (73.0, 334607.0) (74.0, 282511.0) (75.0, 237420.0) (76.0, 198283.0) (77.0, 165175.0) (78.0, 137000.5) (79.0, 113496.0) (80.0, 93876.0) (81.0, 77479.0) (82.0, 63588.0) (83.0, 51473.0) (84.0, 40799.5) (85.0, 31322.0) (86.0, 23101.5) (87.0, 16306.5) (88.0, 11022.0) (89.0, 7195.0) (90.0, 4492.0) (91.0, 2611.0) (92.0, 1450.0) (93.0, 820.0) (94.0, 465.5) (95.0, 252.0) (96.0, 126.0) (97.0, 71.0) (98.0, 44.5) (99.0, 21.0) (100.0, 6.0) high_error_high_variance_R2 (0.0, 515.0) (1.0, 951.5) (2.0, 1835.0) (3.0, 2727.0) (4.0, 3607.0) (5.0, 4614.5) (6.0, 5871.5) (7.0, 7455.0) (8.0, 9486.0) (9.0, 12311.5) (10.0, 16311.0) (11.0, 21932.5) (12.0, 29402.5) (13.0, 40215.5) (14.0, 56021.5) (15.0, 78612.0) (16.0, 111837.5) (17.0, 160504.0) (18.0, 232023.0) (19.0, 335669.0) (20.0, 483323.5) (21.0, 688395.0) (22.0, 963037.0) (23.0, 1320988.0) (24.0, 1772868.5) (25.0, 2321342.0) (26.0, 2959576.5) (27.0, 3674183.0) (28.0, 4445738.5) (29.0, 5244782.5) (30.0, 6041620.0) (31.0, 6800893.0) (32.0, 7497896.0) (33.0, 8110032.0) (34.0, 8613651.0) (35.0, 8997680.5) (36.0, 9250485.5) (37.0, 9373365.5) (38.0, 9372295.5) (39.0, 9256741.0) (40.0, 9045383.5) (41.0, 8756764.0) (42.0, 8407288.0) (43.0, 8017547.5) (44.0, 7602221.0) (45.0, 7182906.0) (46.0, 6776326.5) (47.0, 6383682.5) (48.0, 6008818.5) (49.0, 5652375.0) (50.0, 5313566.5) (51.0, 4989024.5) (52.0, 4682124.5) (53.0, 4394653.0) (54.0, 4125780.0) (55.0, 3870563.5) (56.0, 3615851.5) (57.0, 3362498.0) (58.0, 3108640.5) (59.0, 2847723.5) (60.0, 2581448.5) (61.0, 2314310.0) (62.0, 2050904.0) (63.0, 1797945.0) (64.0, 1563766.5) (65.0, 1350026.5) (66.0, 1155594.5) (67.0, 978542.5) (68.0, 820226.0) (69.0, 684584.5) (70.0, 569535.5) (71.0, 473998.0) (72.0, 397435.0) (73.0, 334691.5) (74.0, 281723.0) (75.0, 237058.0) (76.0, 198979.5) (77.0, 165426.5) (78.0, 137219.5) (79.0, 113636.0) (80.0, 93849.5) (81.0, 77312.0) (82.0, 63458.5) (83.0, 51492.5) (84.0, 40607.5) (85.0, 31268.5) (86.0, 23283.0) (87.0, 16436.0) (88.0, 11055.5) (89.0, 7161.5) (90.0, 4425.0) (91.0, 2598.0) (92.0, 1508.5) (93.0, 826.0) (94.0, 429.5) (95.0, 219.0) (96.0, 115.5) (97.0, 73.0) (98.0, 42.5) (99.0, 25.0) (100.0, 11.5) high_variance_R1 (0.0, 824.0) (1.0, 1285.5) (2.0, 2157.0) (3.0, 3038.5) (4.0, 3936.5) (5.0, 4932.5) (6.0, 6269.0) (7.0, 7895.0) (8.0, 10017.0) (9.0, 13092.5) (10.0, 17402.0) (11.0, 23051.5) (12.0, 31186.5) (13.0, 43040.0) (14.0, 59775.5) (15.0, 83676.0) (16.0, 118686.5) (17.0, 170553.0) (18.0, 246721.5) (19.0, 356089.0) (20.0, 510721.0) (21.0, 723311.5) (22.0, 1007428.0) (23.0, 1376570.5) (24.0, 1838262.5) (25.0, 2398876.5) (26.0, 3048276.0) (27.0, 3764484.5) (28.0, 4534668.0) (29.0, 5332118.0) (30.0, 6117568.0) (31.0, 6868670.5) (32.0, 7552359.5) (33.0, 8143007.5) (34.0, 8630552.0) (35.0, 8995216.5) (36.0, 9229667.0) (37.0, 9333510.0) (38.0, 9315599.5) (39.0, 9190336.0) (40.0, 8971320.5) (41.0, 8676718.0) (42.0, 8327924.0) (43.0, 7939852.0) (44.0, 7530522.5) (45.0, 7116008.0) (46.0, 6708315.0) (47.0, 6320847.0) (48.0, 5953585.5) (49.0, 5603598.0) (50.0, 5268247.5) (51.0, 4949535.5) (52.0, 4647336.5) (53.0, 4363829.5) (54.0, 4102249.0) (55.0, 3850014.5) (56.0, 3600233.0) (57.0, 3351750.5) (58.0, 3098441.5) (59.0, 2840776.5) (60.0, 2579230.0) (61.0, 2315203.5) (62.0, 2055275.0) (63.0, 1804264.0) (64.0, 1570896.5) (65.0, 1357670.5) (66.0, 1163319.0) (67.0, 987941.5) (68.0, 830463.5) (69.0, 693199.0) (70.0, 576896.5) (71.0, 481346.5) (72.0, 403919.0) (73.0, 340678.0) (74.0, 287409.0) (75.0, 241620.0) (76.0, 202557.5) (77.0, 169086.0) (78.0, 140736.0) (79.0, 116671.5) (80.0, 96291.5) (81.0, 79510.5) (82.0, 65419.0) (83.0, 53257.5) (84.0, 42734.0) (85.0, 33076.5) (86.0, 24606.5) (87.0, 17655.0) (88.0, 12044.0) (89.0, 7733.0) (90.0, 4736.5) (91.0, 2843.0) (92.0, 1674.5) (93.0, 925.5) (94.0, 486.5) (95.0, 274.0) (96.0, 158.5) (97.0, 81.5) (98.0, 50.5) (99.0, 35.0) (100.0, 20.0) high_variance_R2 (0.0, 824.0) (1.0, 1277.0) (2.0, 2109.0) (3.0, 2938.0) (4.0, 3869.5) (5.0, 5042.0) (6.0, 6372.5) (7.0, 7914.5) (8.0, 10054.5) (9.0, 13129.0) (10.0, 17339.5) (11.0, 23158.5) (12.0, 31387.5) (13.0, 42969.0) (14.0, 59620.0) (15.0, 83213.5) (16.0, 118288.5) (17.0, 170271.5) (18.0, 245779.0) (19.0, 355381.5) (20.0, 509857.0) (21.0, 723229.5) (22.0, 1008771.5) (23.0, 1376880.5) (24.0, 1839727.0) (25.0, 2400357.5) (26.0, 3048461.0) (27.0, 3765997.5) (28.0, 4537513.0) (29.0, 5333562.5) (30.0, 6120853.0) (31.0, 6870134.5) (32.0, 7547644.0) (33.0, 8137944.5) (34.0, 8627501.5) (35.0, 8993671.5) (36.0, 9230304.0) (37.0, 9336288.5) (38.0, 9315709.0) (39.0, 9188748.5) (40.0, 8970984.0) (41.0, 8679119.0) (42.0, 8330414.5) (43.0, 7939462.5) (44.0, 7530925.0) (45.0, 7118063.0) (46.0, 6708638.5) (47.0, 6320582.5) (48.0, 5954302.5) (49.0, 5604938.5) (50.0, 5270176.5) (51.0, 4949658.5) (52.0, 4645287.0) (53.0, 4363973.5) (54.0, 4100654.5) (55.0, 3846236.0) (56.0, 3600064.5) (57.0, 3350477.0) (58.0, 3096697.5) (59.0, 2842227.0) (60.0, 2580904.0) (61.0, 2313814.5) (62.0, 2053464.5) (63.0, 1804590.0) (64.0, 1571882.0) (65.0, 1359155.5) (66.0, 1164977.5) (67.0, 987984.0) (68.0, 829030.0) (69.0, 692456.5) (70.0, 576456.5) (71.0, 480820.0) (72.0, 403718.5) (73.0, 340410.0) (74.0, 286924.0) (75.0, 241564.0) (76.0, 202522.0) (77.0, 168657.0) (78.0, 140456.0) (79.0, 116693.0) (80.0, 96711.5) (81.0, 79840.5) (82.0, 65414.5) (83.0, 53164.0) (84.0, 42626.0) (85.0, 32983.0) (86.0, 24589.5) (87.0, 17673.5) (88.0, 12079.0) (89.0, 7829.0) (90.0, 4855.5) (91.0, 2948.5) (92.0, 1705.5) (93.0, 940.5) (94.0, 517.5) (95.0, 280.5) (96.0, 149.0) (97.0, 77.5) (98.0, 48.0) (99.0, 29.5) (100.0, 15.0) low_variance_R1 (0.0, 4870.0) (1.0, 4474.0) (2.0, 4238.5) (3.0, 4777.5) (4.0, 5811.0) (5.0, 7232.5) (6.0, 8866.0) (7.0, 11274.5) (8.0, 14766.5) (9.0, 19471.0) (10.0, 26060.0) (11.0, 35088.0) (12.0, 47492.0) (13.0, 65080.5) (14.0, 89694.0) (15.0, 124890.5) (16.0, 177089.0) (17.0, 251851.0) (18.0, 358652.5) (19.0, 511154.5) (20.0, 720403.5) (21.0, 996984.5) (22.0, 1352690.5) (23.0, 1796613.5) (24.0, 2337355.5) (25.0, 2969080.0) (26.0, 3664702.0) (27.0, 4398627.0) (28.0, 5158954.5) (29.0, 5914011.5) (30.0, 6625082.5) (31.0, 7266374.0) (32.0, 7824252.5) (33.0, 8294057.0) (34.0, 8658574.5) (35.0, 8906492.0) (36.0, 9028077.5) (37.0, 9023201.5) (38.0, 8914525.0) (39.0, 8720692.0) (40.0, 8465049.0) (41.0, 8165947.0) (42.0, 7815752.5) (43.0, 7426956.5) (44.0, 7022941.5) (45.0, 6631092.5) (46.0, 6264671.0) (47.0, 5916701.0) (48.0, 5593108.5) (49.0, 5291813.0) (50.0, 4992944.5) (51.0, 4695812.0) (52.0, 4413830.0) (53.0, 4154669.0) (54.0, 3921500.5) (55.0, 3708495.0) (56.0, 3492249.5) (57.0, 3264470.5) (58.0, 3038997.5) (59.0, 2813736.5) (60.0, 2580156.5) (61.0, 2335256.5) (62.0, 2085983.0) (63.0, 1840808.5) (64.0, 1612144.5) (65.0, 1409020.5) (66.0, 1225262.0) (67.0, 1054030.0) (68.0, 895601.5) (69.0, 753791.0) (70.0, 628429.5) (71.0, 521044.0) (72.0, 437856.5) (73.0, 373057.5) (74.0, 320494.5) (75.0, 274720.0) (76.0, 232637.5) (77.0, 196544.0) (78.0, 164634.5) (79.0, 137416.5) (80.0, 115332.0) (81.0, 96459.5) (82.0, 80627.5) (83.0, 67636.0) (84.0, 56611.5) (85.0, 46435.0) (86.0, 37062.0) (87.0, 28333.5) (88.0, 20561.0) (89.0, 14217.0) (90.0, 9398.0) (91.0, 5915.5) (92.0, 3571.5) (93.0, 2080.5) (94.0, 1152.5) (95.0, 599.0) (96.0, 328.5) (97.0, 201.0) (98.0, 112.5) (99.0, 62.0) (100.0, 39.5) low_variance_R2 (0.0, 4887.0) (1.0, 4477.5) (2.0, 4253.0) (3.0, 4830.0) (4.0, 5812.0) (5.0, 7168.0) (6.0, 9008.0) (7.0, 11636.5) (8.0, 15089.0) (9.0, 19705.0) (10.0, 25913.0) (11.0, 34783.0) (12.0, 47334.0) (13.0, 64483.0) (14.0, 89396.5) (15.0, 124940.0) (16.0, 176730.5) (17.0, 251961.0) (18.0, 359357.5) (19.0, 511298.5) (20.0, 719429.5) (21.0, 996576.5) (22.0, 1354375.5) (23.0, 1799726.0) (24.0, 2338325.0) (25.0, 2966902.0) (26.0, 3662480.5) (27.0, 4399777.0) (28.0, 5158409.5) (29.0, 5913994.0) (30.0, 6625114.5) (31.0, 7262887.0) (32.0, 7822109.5) (33.0, 8295665.5) (34.0, 8665659.0) (35.0, 8910516.5) (36.0, 9025129.0) (37.0, 9018742.5) (38.0, 8912155.5) (39.0, 8722548.5) (40.0, 8466021.0) (41.0, 8163914.5) (42.0, 7818768.5) (43.0, 7430000.0) (44.0, 7024576.0) (45.0, 6634029.0) (46.0, 6267053.0) (47.0, 5919327.5) (48.0, 5593002.5) (49.0, 5287611.5) (50.0, 4988119.5) (51.0, 4694990.5) (52.0, 4414228.0) (53.0, 4153860.0) (54.0, 3922314.0) (55.0, 3710135.0) (56.0, 3493026.5) (57.0, 3264825.5) (58.0, 3038582.5) (59.0, 2811251.5) (60.0, 2577996.5) (61.0, 2334337.5) (62.0, 2085393.0) (63.0, 1841097.0) (64.0, 1613512.5) (65.0, 1410398.0) (66.0, 1224875.0) (67.0, 1053402.5) (68.0, 895624.0) (69.0, 752612.0) (70.0, 627734.5) (71.0, 521326.5) (72.0, 436974.5) (73.0, 373152.5) (74.0, 321252.5) (75.0, 274696.0) (76.0, 232389.0) (77.0, 196207.5) (78.0, 164720.5) (79.0, 137513.0) (80.0, 115041.0) (81.0, 96302.0) (82.0, 80571.5) (83.0, 67516.0) (84.0, 56320.5) (85.0, 46167.0) (86.0, 36847.5) (87.0, 28250.0) (88.0, 20590.5) (89.0, 14309.5) (90.0, 9413.5) (91.0, 5900.5) (92.0, 3614.5) (93.0, 2108.0) (94.0, 1199.0) (95.0, 633.5) (96.0, 334.5) (97.0, 194.5) (98.0, 100.5) (99.0, 57.0) (100.0, 42.5) medium_variance_R1 (0.0, 2321.0) (1.0, 2966.0) (2.0, 3873.5) (3.0, 4431.5) (4.0, 5207.0) (5.0, 6322.0) (6.0, 7906.5) (7.0, 9975.0) (8.0, 12912.0) (9.0, 17224.5) (10.0, 22786.0) (11.0, 30542.5) (12.0, 41355.0) (13.0, 56237.5) (14.0, 77985.0) (15.0, 109313.5) (16.0, 154704.0) (17.0, 221158.0) (18.0, 317043.0) (19.0, 453186.0) (20.0, 642280.5) (21.0, 896150.0) (22.0, 1228209.0) (23.0, 1650051.5) (24.0, 2164388.5) (25.0, 2769889.5) (26.0, 3453372.0) (27.0, 4190357.5) (28.0, 4957721.5) (29.0, 5727743.0) (30.0, 6468071.5) (31.0, 7148972.5) (32.0, 7749173.0) (33.0, 8258410.0) (34.0, 8663243.0) (35.0, 8949003.0) (36.0, 9103883.0) (37.0, 9132430.5) (38.0, 9054763.5) (39.0, 8878654.5) (40.0, 8631335.0) (41.0, 8332939.0) (42.0, 7982806.5) (43.0, 7596151.0) (44.0, 7191108.0) (45.0, 6790940.5) (46.0, 6406076.0) (47.0, 6044508.0) (48.0, 5708919.0) (49.0, 5391057.0) (50.0, 5081044.5) (51.0, 4778771.5) (52.0, 4492787.5) (53.0, 4226041.5) (54.0, 3981904.5) (55.0, 3753324.5) (56.0, 3525581.5) (57.0, 3294034.0) (58.0, 3061073.5) (59.0, 2821413.0) (60.0, 2577615.0) (61.0, 2328638.0) (62.0, 2074988.5) (63.0, 1829691.5) (64.0, 1600882.0) (65.0, 1392482.5) (66.0, 1204634.0) (67.0, 1032873.0) (68.0, 874776.0) (69.0, 732201.0) (70.0, 609610.5) (71.0, 508423.5) (72.0, 427205.0) (73.0, 363202.0) (74.0, 309733.0) (75.0, 262890.0) (76.0, 222306.0) (77.0, 187573.5) (78.0, 157116.0) (79.0, 130248.5) (80.0, 108446.0) (81.0, 90872.0) (82.0, 75758.5) (83.0, 63014.5) (84.0, 51807.5) (85.0, 41672.0) (86.0, 32471.5) (87.0, 24198.0) (88.0, 17140.0) (89.0, 11661.5) (90.0, 7598.0) (91.0, 4661.0) (92.0, 2723.5) (93.0, 1588.0) (94.0, 902.0) (95.0, 459.5) (96.0, 262.5) (97.0, 151.0) (98.0, 80.0) (99.0, 52.0) (100.0, 34.0) medium_variance_R2 (0.0, 2291.0) (1.0, 2940.0) (2.0, 3860.5) (3.0, 4469.5) (4.0, 5247.5) (5.0, 6383.0) (6.0, 7915.0) (7.0, 9989.0) (8.0, 13064.0) (9.0, 17114.5) (10.0, 22544.0) (11.0, 30449.0) (12.0, 41391.0) (13.0, 56552.0) (14.0, 78388.5) (15.0, 109694.0) (16.0, 155338.5) (17.0, 220884.0) (18.0, 316231.5) (19.0, 452940.5) (20.0, 642380.5) (21.0, 897333.0) (22.0, 1229765.0) (23.0, 1650145.0) (24.0, 2164103.5) (25.0, 2771394.5) (26.0, 3453040.0) (27.0, 4187975.0) (28.0, 4957726.5) (29.0, 5730963.0) (30.0, 6471927.0) (31.0, 7152562.5) (32.0, 7749241.0) (33.0, 8256748.5) (34.0, 8663191.5) (35.0, 8942025.5) (36.0, 9099257.0) (37.0, 9133631.0) (38.0, 9051391.5) (39.0, 8879702.0) (40.0, 8637402.0) (41.0, 8336464.0) (42.0, 7983125.5) (43.0, 7594648.0) (44.0, 7191110.5) (45.0, 6794365.5) (46.0, 6413795.0) (47.0, 6048030.5) (48.0, 5707905.0) (49.0, 5389922.5) (50.0, 5079878.0) (51.0, 4776255.5) (52.0, 4490099.5) (53.0, 4224074.5) (54.0, 3979581.0) (55.0, 3751961.0) (56.0, 3525858.0) (57.0, 3295079.0) (58.0, 3059100.0) (59.0, 2819820.0) (60.0, 2577935.0) (61.0, 2328826.0) (62.0, 2075718.5) (63.0, 1829863.5) (64.0, 1600603.5) (65.0, 1393423.5) (66.0, 1203572.5) (67.0, 1029486.5) (68.0, 872571.0) (69.0, 732570.5) (70.0, 610054.0) (71.0, 507593.5) (72.0, 425963.5) (73.0, 362378.5) (74.0, 309605.0) (75.0, 263249.5) (76.0, 223072.5) (77.0, 187609.0) (78.0, 156486.0) (79.0, 130312.5) (80.0, 108508.0) (81.0, 90697.5) (82.0, 75881.0) (83.0, 63196.0) (84.0, 52184.0) (85.0, 41946.5) (86.0, 32597.5) (87.0, 24291.5) (88.0, 17304.5) (89.0, 11797.5) (90.0, 7621.0) (91.0, 4700.5) (92.0, 2851.5) (93.0, 1642.0) (94.0, 867.5) (95.0, 457.0) (96.0, 257.0) (97.0, 147.5) (98.0, 78.0) (99.0, 49.5) (100.0, 28.0) only_high_error_zero_var_no_indels_R1 (0.0, 843.0) (1.0, 1304.0) (2.0, 2159.0) (3.0, 3008.5) (4.0, 3935.5) (5.0, 5031.0) (6.0, 6420.0) (7.0, 8010.5) (8.0, 10048.5) (9.0, 13045.5) (10.0, 17175.5) (11.0, 23212.5) (12.0, 31587.0) (13.0, 42928.0) (14.0, 59805.5) (15.0, 84310.0) (16.0, 119433.5) (17.0, 171232.0) (18.0, 247274.5) (19.0, 357380.5) (20.0, 512784.5) (21.0, 726307.5) (22.0, 1011835.5) (23.0, 1381316.0) (24.0, 1845882.0) (25.0, 2407699.5) (26.0, 3055081.5) (27.0, 3774802.0) (28.0, 4547874.0) (29.0, 5343051.5) (30.0, 6128349.0) (31.0, 6876385.5) (32.0, 7558050.5) (33.0, 8148808.0) (34.0, 8632124.5) (35.0, 8991861.0) (36.0, 9222384.0) (37.0, 9327543.0) (38.0, 9310123.0) (39.0, 9178831.0) (40.0, 8958146.5) (41.0, 8667548.5) (42.0, 8319121.0) (43.0, 7930655.0) (44.0, 7518946.5) (45.0, 7106670.0) (46.0, 6703022.0) (47.0, 6313743.5) (48.0, 5947593.0) (49.0, 5602189.5) (50.0, 5268983.5) (51.0, 4949186.5) (52.0, 4647411.5) (53.0, 4363136.5) (54.0, 4097762.5) (55.0, 3845968.0) (56.0, 3599656.5) (57.0, 3351935.0) (58.0, 3098207.0) (59.0, 2841533.0) (60.0, 2582861.5) (61.0, 2317555.5) (62.0, 2055661.0) (63.0, 1805928.5) (64.0, 1573105.5) (65.0, 1359288.0) (66.0, 1163674.0) (67.0, 988202.5) (68.0, 831547.5) (69.0, 694244.5) (70.0, 577561.5) (71.0, 481016.5) (72.0, 402701.5) (73.0, 339431.0) (74.0, 287083.0) (75.0, 241912.0) (76.0, 202637.0) (77.0, 169133.0) (78.0, 140774.0) (79.0, 116459.0) (80.0, 96510.5) (81.0, 79977.0) (82.0, 65721.0) (83.0, 53712.0) (84.0, 42948.5) (85.0, 33152.0) (86.0, 24746.5) (87.0, 17828.5) (88.0, 12149.5) (89.0, 7940.0) (90.0, 5006.0) (91.0, 2962.5) (92.0, 1745.5) (93.0, 998.5) (94.0, 525.5) (95.0, 281.5) (96.0, 139.0) (97.0, 71.5) (98.0, 51.0) (99.0, 32.0) (100.0, 15.0) only_high_error_zero_var_no_indels_R2 (0.0, 868.0) (1.0, 1301.0) (2.0, 2115.0) (3.0, 2960.5) (4.0, 3915.0) (5.0, 5014.0) (6.0, 6276.0) (7.0, 7926.5) (8.0, 10135.0) (9.0, 13119.5) (10.0, 17444.0) (11.0, 23323.5) (12.0, 31636.5) (13.0, 43230.5) (14.0, 59798.5) (15.0, 84235.5) (16.0, 119728.5) (17.0, 171725.5) (18.0, 247293.5) (19.0, 357045.0) (20.0, 513874.5) (21.0, 727689.5) (22.0, 1012455.0) (23.0, 1382132.5) (24.0, 1846596.5) (25.0, 2408516.0) (26.0, 3055880.5) (27.0, 3774603.0) (28.0, 4548139.0) (29.0, 5342657.5) (30.0, 6128483.5) (31.0, 6875922.0) (32.0, 7555082.0) (33.0, 8144960.5) (34.0, 8632589.0) (35.0, 8996846.0) (36.0, 9229651.5) (37.0, 9330645.0) (38.0, 9304418.5) (39.0, 9176818.5) (40.0, 8960127.5) (41.0, 8669717.5) (42.0, 8323196.0) (43.0, 7933930.5) (44.0, 7521897.0) (45.0, 7107001.0) (46.0, 6700603.5) (47.0, 6314183.5) (48.0, 5948033.0) (49.0, 5598179.0) (50.0, 5265811.5) (51.0, 4947032.5) (52.0, 4643016.0) (53.0, 4361776.5) (54.0, 4098645.0) (55.0, 3847375.0) (56.0, 3600417.0) (57.0, 3350829.0) (58.0, 3097505.5) (59.0, 2840729.0) (60.0, 2579379.5) (61.0, 2314022.0) (62.0, 2052963.0) (63.0, 1804486.0) (64.0, 1573319.0) (65.0, 1360460.0) (66.0, 1166232.5) (67.0, 988874.0) (68.0, 830920.0) (69.0, 692937.0) (70.0, 575832.5) (71.0, 481135.0) (72.0, 403484.5) (73.0, 339970.0) (74.0, 287592.5) (75.0, 242059.0) (76.0, 202867.0) (77.0, 169325.5) (78.0, 141186.5) (79.0, 117344.5) (80.0, 96922.5) (81.0, 79945.0) (82.0, 65745.5) (83.0, 53594.5) (84.0, 42800.5) (85.0, 33302.5) (86.0, 24825.5) (87.0, 17602.0) (88.0, 12109.5) (89.0, 7950.0) (90.0, 4937.5) (91.0, 2985.0) (92.0, 1701.5) (93.0, 933.5) (94.0, 525.5) (95.0, 292.0) (96.0, 157.0) (97.0, 89.5) (98.0, 49.5) (99.0, 28.0) (100.0, 14.0) only_high_variance_zero_error_no_indels_R1 (0.0, 547.0) (1.0, 1150.5) (2.0, 2357.0) (3.0, 3457.5) (4.0, 4312.5) (5.0, 5323.0) (6.0, 6626.0) (7.0, 8238.0) (8.0, 10507.0) (9.0, 13620.5) (10.0, 18058.0) (11.0, 24249.5) (12.0, 32822.0) (13.0, 44740.5) (14.0, 62139.5) (15.0, 87844.5) (16.0, 124638.0) (17.0, 178245.5) (18.0, 256629.5) (19.0, 369545.0) (20.0, 529774.5) (21.0, 750922.5) (22.0, 1044946.0) (23.0, 1423812.5) (24.0, 1897751.5) (25.0, 2466073.5) (26.0, 3120212.0) (27.0, 3846779.5) (28.0, 4622137.5) (29.0, 5414116.5) (30.0, 6193604.0) (31.0, 6930553.0) (32.0, 7595465.0) (33.0, 8173448.5) (34.0, 8646556.5) (35.0, 8995540.0) (36.0, 9213819.5) (37.0, 9301799.0) (38.0, 9268897.5) (39.0, 9130455.5) (40.0, 8906205.0) (41.0, 8613901.5) (42.0, 8265760.0) (43.0, 7873544.0) (44.0, 7461198.5) (45.0, 7048689.0) (46.0, 6643982.0) (47.0, 6257831.5) (48.0, 5899893.0) (49.0, 5559791.0) (50.0, 5228193.0) (51.0, 4915478.0) (52.0, 4621763.0) (53.0, 4341772.0) (54.0, 4079342.5) (55.0, 3829114.0) (56.0, 3581610.5) (57.0, 3339702.0) (58.0, 3093868.5) (59.0, 2839576.5) (60.0, 2581184.5) (61.0, 2318968.5) (62.0, 2059376.0) (63.0, 1808664.0) (64.0, 1577523.5) (65.0, 1366568.0) (66.0, 1171304.0) (67.0, 995400.5) (68.0, 838539.5) (69.0, 700609.0) (70.0, 582298.0) (71.0, 484770.5) (72.0, 406786.5) (73.0, 343758.5) (74.0, 291064.0) (75.0, 245641.0) (76.0, 206263.5) (77.0, 172110.5) (78.0, 143022.0) (79.0, 119056.5) (80.0, 98865.5) (81.0, 81669.0) (82.0, 67793.0) (83.0, 55484.0) (84.0, 44299.0) (85.0, 34636.0) (86.0, 26119.0) (87.0, 19040.0) (88.0, 13124.5) (89.0, 8464.5) (90.0, 5241.5) (91.0, 3154.5) (92.0, 1860.5) (93.0, 1061.5) (94.0, 551.0) (95.0, 281.0) (96.0, 150.5) (97.0, 83.0) (98.0, 45.5) (99.0, 23.5) (100.0, 9.0) only_high_variance_zero_error_no_indels_R2 (0.0, 539.0) (1.0, 1119.0) (2.0, 2273.5) (3.0, 3438.5) (4.0, 4405.0) (5.0, 5388.0) (6.0, 6592.0) (7.0, 8299.5) (8.0, 10496.5) (9.0, 13542.5) (10.0, 18005.0) (11.0, 24212.5) (12.0, 32763.0) (13.0, 44849.0) (14.0, 62378.0) (15.0, 87671.5) (16.0, 124541.0) (17.0, 178306.5) (18.0, 256698.5) (19.0, 370349.5) (20.0, 530224.5) (21.0, 750460.5) (22.0, 1045619.5) (23.0, 1424774.0) (24.0, 1895612.5) (25.0, 2462963.5) (26.0, 3119847.5) (27.0, 3847649.5) (28.0, 4624385.5) (29.0, 5416801.0) (30.0, 6195143.5) (31.0, 6930578.5) (32.0, 7597014.0) (33.0, 8173128.5) (34.0, 8641032.0) (35.0, 8992775.0) (36.0, 9213715.0) (37.0, 9301176.0) (38.0, 9269374.5) (39.0, 9134291.0) (40.0, 8909499.0) (41.0, 8611582.5) (42.0, 8260741.5) (43.0, 7873741.0) (44.0, 7461011.5) (45.0, 7046736.5) (46.0, 6645439.0) (47.0, 6263612.0) (48.0, 5902601.0) (49.0, 5558119.0) (50.0, 5229441.5) (51.0, 4914004.5) (52.0, 4616534.0) (53.0, 4337202.5) (54.0, 4078468.5) (55.0, 3830325.0) (56.0, 3586305.5) (57.0, 3341288.0) (58.0, 3091304.5) (59.0, 2839526.0) (60.0, 2581993.0) (61.0, 2318962.5) (62.0, 2057950.0) (63.0, 1808695.0) (64.0, 1577838.5) (65.0, 1366503.5) (66.0, 1171493.5) (67.0, 996028.0) (68.0, 839503.5) (69.0, 700113.0) (70.0, 582190.5) (71.0, 485938.0) (72.0, 407817.5) (73.0, 344078.0) (74.0, 291421.0) (75.0, 245770.5) (76.0, 206079.5) (77.0, 172003.5) (78.0, 143066.0) (79.0, 119244.5) (80.0, 99029.0) (81.0, 81921.0) (82.0, 67616.0) (83.0, 55314.0) (84.0, 44259.5) (85.0, 34519.5) (86.0, 26034.5) (87.0, 18873.0) (88.0, 12937.0) (89.0, 8373.0) (90.0, 5184.5) (91.0, 3059.0) (92.0, 1845.0) (93.0, 1067.5) (94.0, 554.0) (95.0, 267.0) (96.0, 147.0) (97.0, 91.5) (98.0, 56.0) (99.0, 27.5) (100.0, 11.5) only_low_error_zero_var_no_indels_R1 (0.0, 5147.0) (1.0, 4648.5) (2.0, 4307.0) (3.0, 4887.0) (4.0, 5882.5) (5.0, 7190.0) (6.0, 8989.0) (7.0, 11571.0) (8.0, 14919.5) (9.0, 19669.0) (10.0, 26337.0) (11.0, 35286.5) (12.0, 47677.0) (13.0, 65012.0) (14.0, 89699.5) (15.0, 125750.0) (16.0, 177923.5) (17.0, 252753.0) (18.0, 360786.0) (19.0, 513464.5) (20.0, 723160.5) (21.0, 1000263.0) (22.0, 1357335.0) (23.0, 1806018.0) (24.0, 2347596.5) (25.0, 2975140.0) (26.0, 3670832.0) (27.0, 4409190.5) (28.0, 5167030.5) (29.0, 5920909.5) (30.0, 6630596.5) (31.0, 7269891.5) (32.0, 7828489.0) (33.0, 8294185.0) (34.0, 8656630.5) (35.0, 8903026.5) (36.0, 9023254.0) (37.0, 9020559.0) (38.0, 8912790.0) (39.0, 8716223.5) (40.0, 8459496.0) (41.0, 8156767.0) (42.0, 7806125.5) (43.0, 7418719.5) (44.0, 7018675.5) (45.0, 6630387.5) (46.0, 6262928.0) (47.0, 5914294.5) (48.0, 5588581.5) (49.0, 5285979.5) (50.0, 4985163.0) (51.0, 4689094.0) (52.0, 4411231.5) (53.0, 4152357.5) (54.0, 3918415.5) (55.0, 3706603.5) (56.0, 3490818.5) (57.0, 3263264.5) (58.0, 3037586.0) (59.0, 2812785.5) (60.0, 2580184.5) (61.0, 2336643.5) (62.0, 2085511.0) (63.0, 1838971.5) (64.0, 1612288.0) (65.0, 1409471.0) (66.0, 1226933.0) (67.0, 1055365.5) (68.0, 895061.5) (69.0, 752535.0) (70.0, 627568.5) (71.0, 522088.5) (72.0, 438954.0) (73.0, 374456.5) (74.0, 321488.0) (75.0, 274458.0) (76.0, 233110.5) (77.0, 197259.5) (78.0, 165569.0) (79.0, 138549.0) (80.0, 116006.5) (81.0, 96945.0) (82.0, 81017.0) (83.0, 67984.5) (84.0, 56654.5) (85.0, 46482.0) (86.0, 36996.5) (87.0, 28226.0) (88.0, 20738.0) (89.0, 14382.5) (90.0, 9496.0) (91.0, 5964.0) (92.0, 3639.5) (93.0, 2185.5) (94.0, 1209.0) (95.0, 614.0) (96.0, 348.0) (97.0, 204.0) (98.0, 111.0) (99.0, 63.5) (100.0, 49.5) only_low_error_zero_var_no_indels_R2 (0.0, 5082.0) (1.0, 4613.5) (2.0, 4287.5) (3.0, 4862.5) (4.0, 5802.5) (5.0, 7164.0) (6.0, 9025.5) (7.0, 11424.5) (8.0, 14916.5) (9.0, 19723.5) (10.0, 26153.5) (11.0, 35267.0) (12.0, 47631.0) (13.0, 65001.0) (14.0, 89869.5) (15.0, 125505.5) (16.0, 177905.5) (17.0, 253568.0) (18.0, 361240.5) (19.0, 513179.5) (20.0, 723415.5) (21.0, 1001919.0) (22.0, 1359317.0) (23.0, 1806905.0) (24.0, 2347802.0) (25.0, 2978551.5) (26.0, 3674777.0) (27.0, 4408827.0) (28.0, 5166679.0) (29.0, 5922622.0) (30.0, 6634309.5) (31.0, 7271967.0) (32.0, 7824057.5) (33.0, 8292408.0) (34.0, 8661269.0) (35.0, 8904222.0) (36.0, 9019049.0) (37.0, 9018788.0) (38.0, 8914190.5) (39.0, 8716261.5) (40.0, 8458187.0) (41.0, 8155998.5) (42.0, 7806076.5) (43.0, 7416481.0) (44.0, 7013194.5) (45.0, 6626684.0) (46.0, 6262598.0) (47.0, 5913790.0) (48.0, 5586738.5) (49.0, 5285143.0) (50.0, 4990449.0) (51.0, 4693459.5) (52.0, 4408323.0) (53.0, 4148988.0) (54.0, 3918671.5) (55.0, 3706526.5) (56.0, 3490956.5) (57.0, 3263902.5) (58.0, 3036855.0) (59.0, 2811048.0) (60.0, 2577679.5) (61.0, 2334598.5) (62.0, 2085077.5) (63.0, 1840057.5) (64.0, 1612472.0) (65.0, 1409134.0) (66.0, 1225614.5) (67.0, 1055222.0) (68.0, 896266.0) (69.0, 754024.5) (70.0, 629692.5) (71.0, 522625.0) (72.0, 438657.5) (73.0, 374115.0) (74.0, 321280.0) (75.0, 275004.5) (76.0, 233491.0) (77.0, 197261.5) (78.0, 165773.5) (79.0, 138698.0) (80.0, 116165.0) (81.0, 96963.0) (82.0, 80841.5) (83.0, 68009.0) (84.0, 56940.5) (85.0, 46519.0) (86.0, 37082.5) (87.0, 28278.5) (88.0, 20557.0) (89.0, 14337.5) (90.0, 9478.5) (91.0, 6024.5) (92.0, 3690.0) (93.0, 2148.5) (94.0, 1191.0) (95.0, 633.5) (96.0, 351.0) (97.0, 213.5) (98.0, 118.5) (99.0, 72.5) (100.0, 55.5) only_low_variance_zero_error_no_indels_R1 (0.0, 5203.0) (1.0, 4624.5) (2.0, 4251.5) (3.0, 4868.0) (4.0, 5838.0) (5.0, 7177.5) (6.0, 8909.5) (7.0, 11409.0) (8.0, 14998.0) (9.0, 19939.0) (10.0, 26560.0) (11.0, 35389.5) (12.0, 47790.0) (13.0, 65249.0) (14.0, 89871.0) (15.0, 125693.5) (16.0, 178279.5) (17.0, 253342.0) (18.0, 361180.0) (19.0, 514251.0) (20.0, 724411.5) (21.0, 1002613.5) (22.0, 1359781.0) (23.0, 1807566.0) (24.0, 2348456.0) (25.0, 2977600.0) (26.0, 3672756.5) (27.0, 4407934.0) (28.0, 5167301.5) (29.0, 5920099.0) (30.0, 6630271.0) (31.0, 7267287.0) (32.0, 7823526.0) (33.0, 8293520.0) (34.0, 8655173.0) (35.0, 8902226.0) (36.0, 9024058.0) (37.0, 9018487.5) (38.0, 8905868.0) (39.0, 8711113.0) (40.0, 8460263.0) (41.0, 8159771.0) (42.0, 7809205.0) (43.0, 7420254.0) (44.0, 7016965.5) (45.0, 6624785.0) (46.0, 6258685.0) (47.0, 5913360.0) (48.0, 5587933.5) (49.0, 5285408.5) (50.0, 4986214.5) (51.0, 4691275.5) (52.0, 4412284.5) (53.0, 4154036.0) (54.0, 3920936.0) (55.0, 3707721.0) (56.0, 3490992.0) (57.0, 3263831.0) (58.0, 3038593.0) (59.0, 2811845.0) (60.0, 2577539.5) (61.0, 2334823.0) (62.0, 2087602.0) (63.0, 1841219.0) (64.0, 1612404.5) (65.0, 1409701.5) (66.0, 1225418.5) (67.0, 1055229.5) (68.0, 896919.0) (69.0, 753352.0) (70.0, 628357.5) (71.0, 523162.5) (72.0, 439787.0) (73.0, 374535.0) (74.0, 321237.5) (75.0, 274502.0) (76.0, 233112.5) (77.0, 197463.5) (78.0, 165621.5) (79.0, 138447.0) (80.0, 115858.5) (81.0, 96849.5) (82.0, 80944.0) (83.0, 67958.0) (84.0, 57130.5) (85.0, 47021.5) (86.0, 37281.5) (87.0, 28343.0) (88.0, 20663.0) (89.0, 14408.5) (90.0, 9578.0) (91.0, 5993.0) (92.0, 3628.5) (93.0, 2140.5) (94.0, 1210.5) (95.0, 638.5) (96.0, 357.0) (97.0, 209.5) (98.0, 106.5) (99.0, 69.5) (100.0, 52.5) only_low_variance_zero_error_no_indels_R2 (0.0, 5220.0) (1.0, 4627.5) (2.0, 4217.5) (3.0, 4835.0) (4.0, 5865.5) (5.0, 7211.5) (6.0, 8920.5) (7.0, 11239.5) (8.0, 14792.0) (9.0, 19652.5) (10.0, 26132.0) (11.0, 35363.0) (12.0, 47723.5) (13.0, 65001.0) (14.0, 89763.5) (15.0, 125683.5) (16.0, 178443.0) (17.0, 253977.5) (18.0, 362245.0) (19.0, 514818.5) (20.0, 724258.0) (21.0, 1001640.5) (22.0, 1359837.0) (23.0, 1807649.5) (24.0, 2347367.0) (25.0, 2977729.0) (26.0, 3674319.5) (27.0, 4408410.0) (28.0, 5168376.5) (29.0, 5924843.5) (30.0, 6634329.0) (31.0, 7269169.5) (32.0, 7824599.5) (33.0, 8293482.5) (34.0, 8654262.5) (35.0, 8898236.5) (36.0, 9019089.5) (37.0, 9015827.5) (38.0, 8906618.5) (39.0, 8712616.0) (40.0, 8458657.0) (41.0, 8156851.5) (42.0, 7808665.5) (43.0, 7420160.0) (44.0, 7016488.0) (45.0, 6627831.5) (46.0, 6259995.0) (47.0, 5911594.0) (48.0, 5586923.0) (49.0, 5284885.5) (50.0, 4987266.5) (51.0, 4692156.0) (52.0, 4410665.0) (53.0, 4148908.5) (54.0, 3917168.5) (55.0, 3706900.0) (56.0, 3492197.5) (57.0, 3266236.0) (58.0, 3040326.5) (59.0, 2812261.0) (60.0, 2577404.0) (61.0, 2334440.5) (62.0, 2085432.5) (63.0, 1842622.5) (64.0, 1614583.5) (65.0, 1409952.0) (66.0, 1226991.5) (67.0, 1055883.5) (68.0, 897174.5) (69.0, 754483.0) (70.0, 628999.0) (71.0, 523513.5) (72.0, 439730.5) (73.0, 374495.0) (74.0, 321339.0) (75.0, 274714.0) (76.0, 233040.5) (77.0, 197249.0) (78.0, 165796.0) (79.0, 138527.5) (80.0, 115619.5) (81.0, 96742.0) (82.0, 81000.0) (83.0, 68027.0) (84.0, 56896.5) (85.0, 46628.0) (86.0, 37162.0) (87.0, 28299.0) (88.0, 20605.0) (89.0, 14402.0) (90.0, 9480.5) (91.0, 5917.0) (92.0, 3685.0) (93.0, 2137.0) (94.0, 1218.0) (95.0, 653.0) (96.0, 327.5) (97.0, 194.0) (98.0, 109.0) (99.0, 65.5) (100.0, 47.5) only_medium_error_zero_var_no_indels_R1 (0.0, 3262.0) (1.0, 3618.5) (2.0, 4195.5) (3.0, 4672.5) (4.0, 5540.5) (5.0, 6857.5) (6.0, 8466.0) (7.0, 10683.0) (8.0, 13936.0) (9.0, 18337.5) (10.0, 24158.0) (11.0, 32688.5) (12.0, 44370.0) (13.0, 60307.5) (14.0, 83398.0) (15.0, 116887.0) (16.0, 165436.0) (17.0, 236288.0) (18.0, 338031.5) (19.0, 481554.5) (20.0, 680408.5) (21.0, 945808.0) (22.0, 1289852.0) (23.0, 1722928.5) (24.0, 2249699.0) (25.0, 2868277.0) (26.0, 3557592.0) (27.0, 4292438.5) (28.0, 5058065.0) (29.0, 5823878.5) (30.0, 6551156.5) (31.0, 7209035.5) (32.0, 7785361.5) (33.0, 8274658.5) (34.0, 8661604.5) (35.0, 8927728.5) (36.0, 9064930.0) (37.0, 9079132.0) (38.0, 8983441.5) (39.0, 8799669.0) (40.0, 8550473.0) (41.0, 8248195.5) (42.0, 7900255.5) (43.0, 7515184.0) (44.0, 7110284.0) (45.0, 6712739.5) (46.0, 6335345.5) (47.0, 5981688.5) (48.0, 5651030.0) (49.0, 5339442.0) (50.0, 5034817.0) (51.0, 4736191.5) (52.0, 4451919.5) (53.0, 4190196.0) (54.0, 3951709.0) (55.0, 3730652.5) (56.0, 3510014.0) (57.0, 3280883.0) (58.0, 3050717.5) (59.0, 2815935.5) (60.0, 2578290.5) (61.0, 2332985.0) (62.0, 2081762.0) (63.0, 1835348.0) (64.0, 1606675.5) (65.0, 1400623.5) (66.0, 1214569.0) (67.0, 1043840.0) (68.0, 884304.5) (69.0, 741933.5) (70.0, 618233.5) (71.0, 514901.5) (72.0, 433235.5) (73.0, 368088.5) (74.0, 314006.0) (75.0, 267574.5) (76.0, 227091.5) (77.0, 192222.0) (78.0, 161370.5) (79.0, 134537.5) (80.0, 112057.5) (81.0, 93541.0) (82.0, 78253.0) (83.0, 65182.0) (84.0, 54326.5) (85.0, 44468.0) (86.0, 34862.0) (87.0, 26143.5) (88.0, 18779.5) (89.0, 12916.5) (90.0, 8462.5) (91.0, 5250.5) (92.0, 3199.0) (93.0, 1853.0) (94.0, 1010.0) (95.0, 536.0) (96.0, 283.0) (97.0, 178.0) (98.0, 116.0) (99.0, 68.5) (100.0, 38.0) only_medium_error_zero_var_no_indels_R2 (0.0, 3278.0) (1.0, 3695.5) (2.0, 4208.0) (3.0, 4672.0) (4.0, 5451.5) (5.0, 6643.5) (6.0, 8410.0) (7.0, 10766.0) (8.0, 13896.0) (9.0, 18317.0) (10.0, 24257.0) (11.0, 32676.5) (12.0, 44344.5) (13.0, 60341.0) (14.0, 83405.0) (15.0, 116930.5) (16.0, 165479.5) (17.0, 235789.0) (18.0, 337170.5) (19.0, 480707.5) (20.0, 679937.0) (21.0, 945841.0) (22.0, 1290260.0) (23.0, 1724404.5) (24.0, 2252685.5) (25.0, 2869297.5) (26.0, 3557382.0) (27.0, 4293575.5) (28.0, 5057372.5) (29.0, 5820630.0) (30.0, 6548196.0) (31.0, 7208957.5) (32.0, 7787790.5) (33.0, 8277838.0) (34.0, 8661193.0) (35.0, 8925447.5) (36.0, 9066656.5) (37.0, 9081756.5) (38.0, 8985606.5) (39.0, 8801541.5) (40.0, 8552578.5) (41.0, 8249349.0) (42.0, 7898104.0) (43.0, 7513840.5) (44.0, 7108552.0) (45.0, 6710460.0) (46.0, 6335924.0) (47.0, 5982490.0) (48.0, 5649121.5) (49.0, 5336763.5) (50.0, 5034866.0) (51.0, 4736240.0) (52.0, 4449164.0) (53.0, 4186104.5) (54.0, 3949838.0) (55.0, 3731000.5) (56.0, 3509936.5) (57.0, 3280351.0) (58.0, 3051200.5) (59.0, 2818380.5) (60.0, 2581027.5) (61.0, 2333680.5) (62.0, 2080480.5) (63.0, 1835007.5) (64.0, 1606296.0) (65.0, 1401924.5) (66.0, 1215707.0) (67.0, 1041654.0) (68.0, 883971.5) (69.0, 742677.5) (70.0, 618112.5) (71.0, 515423.5) (72.0, 433012.5) (73.0, 367989.5) (74.0, 315348.0) (75.0, 268896.5) (76.0, 227601.0) (77.0, 191920.5) (78.0, 160947.0) (79.0, 134478.5) (80.0, 112217.0) (81.0, 93607.0) (82.0, 78334.0) (83.0, 65447.5) (84.0, 54364.5) (85.0, 44065.5) (86.0, 34723.0) (87.0, 26190.5) (88.0, 18796.5) (89.0, 13055.5) (90.0, 8569.5) (91.0, 5303.0) (92.0, 3214.5) (93.0, 1855.5) (94.0, 996.0) (95.0, 533.0) (96.0, 285.0) (97.0, 174.0) (98.0, 92.5) (99.0, 54.5) (100.0, 42.0) only_medium_variance_zero_error_no_indels_R1 (0.0, 3298.0) (1.0, 3677.5) (2.0, 4218.0) (3.0, 4716.0) (4.0, 5510.5) (5.0, 6791.5) (6.0, 8515.5) (7.0, 10782.5) (8.0, 14059.0) (9.0, 18556.5) (10.0, 24506.5) (11.0, 32999.5) (12.0, 44682.0) (13.0, 61040.5) (14.0, 84286.5) (15.0, 117923.5) (16.0, 167289.0) (17.0, 238286.0) (18.0, 339956.0) (19.0, 484754.0) (20.0, 685399.5) (21.0, 953587.0) (22.0, 1300257.0) (23.0, 1734142.5) (24.0, 2261645.0) (25.0, 2880844.5) (26.0, 3572567.0) (27.0, 4307174.0) (28.0, 5067773.0) (29.0, 5831792.5) (30.0, 6558647.5) (31.0, 7217352.0) (32.0, 7794766.5) (33.0, 8280195.5) (34.0, 8660909.5) (35.0, 8922696.0) (36.0, 9056433.5) (37.0, 9072025.5) (38.0, 8979219.0) (39.0, 8792873.0) (40.0, 8539941.0) (41.0, 8234325.0) (42.0, 7886023.0) (43.0, 7501064.5) (44.0, 7095114.0) (45.0, 6700943.0) (46.0, 6328188.0) (47.0, 5975996.5) (48.0, 5644653.5) (49.0, 5332336.0) (50.0, 5028526.0) (51.0, 4730436.5) (52.0, 4447244.0) (53.0, 4183559.5) (54.0, 3945072.0) (55.0, 3725825.0) (56.0, 3507083.0) (57.0, 3279765.0) (58.0, 3050110.5) (59.0, 2820035.0) (60.0, 2580819.0) (61.0, 2332387.5) (62.0, 2082406.5) (63.0, 1836833.0) (64.0, 1607621.0) (65.0, 1401944.5) (66.0, 1215399.5) (67.0, 1043050.0) (68.0, 885269.5) (69.0, 743298.5) (70.0, 620440.0) (71.0, 516988.5) (72.0, 433415.0) (73.0, 368598.0) (74.0, 316394.5) (75.0, 269946.5) (76.0, 228118.0) (77.0, 192505.5) (78.0, 161511.0) (79.0, 134951.5) (80.0, 112768.0) (81.0, 94044.5) (82.0, 78489.5) (83.0, 65780.0) (84.0, 54751.5) (85.0, 44477.5) (86.0, 35021.5) (87.0, 26566.0) (88.0, 18913.0) (89.0, 12854.0) (90.0, 8503.0) (91.0, 5394.0) (92.0, 3243.5) (93.0, 1873.5) (94.0, 999.0) (95.0, 524.5) (96.0, 302.0) (97.0, 178.0) (98.0, 93.0) (99.0, 53.0) (100.0, 41.0) only_medium_variance_zero_error_no_indels_R2 (0.0, 3516.0) (1.0, 3790.0) (2.0, 4236.0) (3.0, 4743.5) (4.0, 5594.0) (5.0, 6925.5) (6.0, 8662.0) (7.0, 10897.5) (8.0, 13990.5) (9.0, 18456.0) (10.0, 24513.5) (11.0, 32987.5) (12.0, 44673.0) (13.0, 60971.0) (14.0, 84317.5) (15.0, 117987.0) (16.0, 167494.0) (17.0, 238557.0) (18.0, 340536.0) (19.0, 484886.0) (20.0, 684551.5) (21.0, 951722.0) (22.0, 1297741.5) (23.0, 1732430.5) (24.0, 2262537.0) (25.0, 2883926.0) (26.0, 3572620.5) (27.0, 4309852.0) (28.0, 5073244.5) (29.0, 5833030.5) (30.0, 6560150.5) (31.0, 7219005.5) (32.0, 7793595.0) (33.0, 8277897.5) (34.0, 8658483.5) (35.0, 8919722.0) (36.0, 9059048.5) (37.0, 9074588.5) (38.0, 8976803.5) (39.0, 8791137.5) (40.0, 8540274.0) (41.0, 8238329.5) (42.0, 7886808.5) (43.0, 7497920.5) (44.0, 7093654.0) (45.0, 6698308.5) (46.0, 6325418.0) (47.0, 5975447.5) (48.0, 5643397.5) (49.0, 5329419.0) (50.0, 5025357.0) (51.0, 4730051.0) (52.0, 4450583.0) (53.0, 4187111.5) (54.0, 3946066.5) (55.0, 3727566.0) (56.0, 3509413.0) (57.0, 3280087.0) (58.0, 3049786.0) (59.0, 2818237.0) (60.0, 2579602.5) (61.0, 2332205.5) (62.0, 2081480.0) (63.0, 1836040.0) (64.0, 1608188.5) (65.0, 1403216.5) (66.0, 1215869.0) (67.0, 1043530.5) (68.0, 885138.5) (69.0, 743305.5) (70.0, 619780.5) (71.0, 516308.0) (72.0, 434560.5) (73.0, 369318.5) (74.0, 315972.5) (75.0, 270146.5) (76.0, 228992.0) (77.0, 192776.5) (78.0, 161252.0) (79.0, 134535.5) (80.0, 112173.5) (81.0, 93709.0) (82.0, 78610.0) (83.0, 65631.5) (84.0, 54564.5) (85.0, 44629.0) (86.0, 35085.5) (87.0, 26445.5) (88.0, 18986.5) (89.0, 12987.5) (90.0, 8459.5) (91.0, 5275.0) (92.0, 3210.5) (93.0, 1883.5) (94.0, 1076.5) (95.0, 573.0) (96.0, 304.0) (97.0, 170.5) (98.0, 105.5) (99.0, 71.0) (100.0, 43.5) reference_clean_R1 (0.0, 5501.0) (1.0, 4736.0) (2.0, 4233.0) (3.0, 4946.5) (4.0, 5979.5) (5.0, 7277.5) (6.0, 9038.5) (7.0, 11627.5) (8.0, 15099.5) (9.0, 20024.0) (10.0, 26737.0) (11.0, 35647.0) (12.0, 48022.0) (13.0, 65780.0) (14.0, 90689.0) (15.0, 126580.0) (16.0, 179819.5) (17.0, 256124.0) (18.0, 364677.0) (19.0, 517660.5) (20.0, 728517.0) (21.0, 1008947.0) (22.0, 1367866.5) (23.0, 1816812.0) (24.0, 2360270.5) (25.0, 2989870.5) (26.0, 3685015.5) (27.0, 4421660.5) (28.0, 5182254.5) (29.0, 5934533.5) (30.0, 6641020.5) (31.0, 7277346.5) (32.0, 7831077.0) (33.0, 8297552.0) (34.0, 8660822.5) (35.0, 8902598.0) (36.0, 9015588.5) (37.0, 9007199.5) (38.0, 8897660.5) (39.0, 8700917.0) (40.0, 8443922.0) (41.0, 8143490.5) (42.0, 7795799.5) (43.0, 7409327.5) (44.0, 7005006.5) (45.0, 6615839.0) (46.0, 6252352.5) (47.0, 5903670.0) (48.0, 5578971.0) (49.0, 5280235.5) (50.0, 4981823.0) (51.0, 4686345.0) (52.0, 4408961.5) (53.0, 4150308.5) (54.0, 3916239.0) (55.0, 3704799.5) (56.0, 3489491.0) (57.0, 3263547.0) (58.0, 3037667.0) (59.0, 2811357.5) (60.0, 2579234.5) (61.0, 2336089.0) (62.0, 2086593.5) (63.0, 1841398.0) (64.0, 1614270.5) (65.0, 1410554.0) (66.0, 1226390.5) (67.0, 1055793.5) (68.0, 897080.5) (69.0, 754348.0) (70.0, 629188.5) (71.0, 523312.0) (72.0, 439568.0) (73.0, 375117.5) (74.0, 322833.0) (75.0, 275305.5) (76.0, 233521.0) (77.0, 197975.0) (78.0, 166057.0) (79.0, 138656.0) (80.0, 115742.5) (81.0, 96637.5) (82.0, 81027.5) (83.0, 67895.5) (84.0, 56429.0) (85.0, 46391.0) (86.0, 37388.5) (87.0, 28606.5) (88.0, 20955.5) (89.0, 14684.5) (90.0, 9587.0) (91.0, 6020.0) (92.0, 3725.5) (93.0, 2271.0) (94.0, 1269.0) (95.0, 647.5) (96.0, 362.0) (97.0, 207.5) (98.0, 110.5) (99.0, 68.0) (100.0, 58.0) reference_clean_R2 (0.0, 5344.0) (1.0, 4676.0) (2.0, 4220.5) (3.0, 4883.5) (4.0, 5939.5) (5.0, 7269.5) (6.0, 8961.5) (7.0, 11452.0) (8.0, 15088.5) (9.0, 19996.5) (10.0, 26588.5) (11.0, 35648.0) (12.0, 48173.0) (13.0, 65678.0) (14.0, 90689.0) (15.0, 126725.5) (16.0, 178932.5) (17.0, 254792.0) (18.0, 364044.0) (19.0, 517960.0) (20.0, 729221.0) (21.0, 1009180.0) (22.0, 1369080.0) (23.0, 1816822.0) (24.0, 2358858.5) (25.0, 2988287.5) (26.0, 3686323.0) (27.0, 4423308.5) (28.0, 5177742.0) (29.0, 5930075.0) (30.0, 6637719.5) (31.0, 7274132.5) (32.0, 7829293.0) (33.0, 8296848.0) (34.0, 8661678.5) (35.0, 8900947.0) (36.0, 9014594.5) (37.0, 9008992.0) (38.0, 8900578.5) (39.0, 8706658.0) (40.0, 8448300.0) (41.0, 8146682.5) (42.0, 7795715.0) (43.0, 7407946.5) (44.0, 7009676.0) (45.0, 6621099.0) (46.0, 6252539.5) (47.0, 5903311.0) (48.0, 5581394.5) (49.0, 5282599.5) (50.0, 4984503.5) (51.0, 4685273.0) (52.0, 4403707.5) (53.0, 4147829.0) (54.0, 3914983.5) (55.0, 3703479.0) (56.0, 3489938.5) (57.0, 3263056.0) (58.0, 3035919.5) (59.0, 2809727.5) (60.0, 2578223.0) (61.0, 2335580.5) (62.0, 2086133.0) (63.0, 1843002.0) (64.0, 1615051.5) (65.0, 1410158.5) (66.0, 1226739.5) (67.0, 1055372.0) (68.0, 897166.5) (69.0, 754889.5) (70.0, 629799.5) (71.0, 523899.5) (72.0, 439342.5) (73.0, 374759.5) (74.0, 322076.0) (75.0, 275250.0) (76.0, 234049.0) (77.0, 197876.0) (78.0, 165877.0) (79.0, 138542.5) (80.0, 116154.5) (81.0, 97071.0) (82.0, 81064.5) (83.0, 68076.0) (84.0, 56874.5) (85.0, 46864.5) (86.0, 37212.0) (87.0, 28357.5) (88.0, 20872.0) (89.0, 14516.0) (90.0, 9624.0) (91.0, 6114.5) (92.0, 3717.0) (93.0, 2167.0) (94.0, 1206.0) (95.0, 633.0) (96.0, 335.0) (97.0, 204.0) (98.0, 121.0) (99.0, 72.0) (100.0, 50.5)